D Dimer Assay
نویسنده
چکیده
Introduction A new test for determination of circulating fibrin degradation products has recently been marketed in the U.S. Known genericaUy as the D-dimer assay, it is a direct latex agglutination assay employing monoclonal anubody specific for digestion products of crosslinked fibrin. It is offered as an alternative to or replacement for the widely available Thrombo-Wellcotest assay for fibrinogen and fibrin degradation products. Whereas the present test is used almost exclusively in the setting of disseminated intravascular coagulation (DIQ, the D-dimer assay is purported to have diagnostic utility in a wider range of thrombotic disorders eg deep venous thrombosis (DVT) with or without pulmonary embolism (PE), arterial thrombosis, and DIC [1].
منابع مشابه
The Effect of Preanalytical, Analytical, and Postanalytical Variables on D-dimer Measurement
D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoa...
متن کاملEvaluation of Correlation between D-dimer Levels with Disease Severity in Patients with Covid-19 Referred to Hamedan Besat Hospital in 2021-2022
Introduction: The Covid-19 virus affects the hemostasis system in infected people by causing thrombosis and it increases the level of D_dimer. This study was designed and conducted for the evaluation of correlation between D-dimer levels with disease severity in patients with Covid-19 referred to Hamedan Besat hospital. Methods and Materials: 366 patients with Covid-19 referred to Besat Hospit...
متن کاملبررسی قدرت تست D-Dimer در تشخیص ترومبوس دهلیزی درمبتلایان به فیبریلاسیون دهلیزی
سابقه و هدف: با توجه به نگرانی از بروز ترومبوس دهلیزی در بیماران فیبریلاسیون دهلیزی و اهمیت تشخیص سریع آن و گزارش مواردی از موفقیت تست D-Dimer در تشخیص ترومبوس و عدم وجود مطالعه ای در کشور به منظور تعیین قدرت تست D-Dimer نسبت به استاندارد طلایی اکوی ترانس ازوفاژیال این تحقیق روی مراجعین به بیمارستان مدرس انجام گرفت. مواد و روش ها: تحقیق با طراحی کار آزمایی بالینی از نوع تشخیصی بر روی بیماران مب...
متن کاملThe value of D-Dimer as a biomarker in assessing disease severity and mortality in patients with Covid-19, a review study
The Covid-19 pandemic created by the 2019 Coronavirus-nCov has become one of the biggest health problems of the current century. Because this disease is new in human society and has no previous history, so our information about it is incomplete, and researchers are trying to study with extensive clinical studies and changes in the human body caused by the function of this virus. It is clear tha...
متن کاملSensitivity and specificity of a quantitative point of care D-dimer assay using heparinized whole blood, in patients with clinically suspected deep vein thrombosis.
D-dimer assays are efficient in the exclusion diagnostics of deep vein thrombosis (DVT) in patients without severe concomitant diseases. We have determined diagnostic sensitivity and specificity of a new point-of-care rapid assay for quantitative determination of D-dimer in heparinized whole blood in outpatients with suspected DVT. In 19 participating centers, 637 patients were included in the ...
متن کاملA negative D-dimer assay does not rule out cerebral venous thrombosis: a series of seventy-three patients.
BACKGROUND AND PURPOSE Cerebral venous thrombosis (CVT) is an infrequent variety of cerebrovascular disease with a wide spectrum of clinical presentations and a notoriously difficult diagnosis. Previous reports have emphasized the potential clinical utility of D-dimer assay in CVT diagnosis. METHODS A rapid sensitive D-dimer assay was performed at entry in 73 patients with CVT <30 days durati...
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